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They resist DPP-4 degradation, creating sustained receptor activation that lasts days (semaglutide has a half-life of approximately 168 hours)

When food moves more slowly through the digestive tract, it can change how nutrients are absorbed, how full you feel, and how gut microbes interact with what you eat

GLP-1 acts on neurons in the hypothalamus, a brain region that controls hunger and satiety, making us feel full without a full stomach 2

Up-Regulation of leucocytes genes implicated in telomere dysfunction and cellular senescence correlates with depression and anxiety severity scores