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Biological systems tend toward homeostasis, and prolonged interference with any single pathway component may trigger adaptive responses

Administration of a dipeptidyl peptidase IV inhibitor enhances the intestinal adaptation in a mouse model of short bowel syndrome

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Individuals prescribed either treatment in the past year before cohort entry were excluded

Canadian Alternatives for US Patients Given the high cost of Linzess in the United States, some US patients have explored the option of obtaining the medication from Canada, where prescription drug prices tend to be more affordable