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The exact way semaglutide might benefit psoriasis patients isnt fully understood yet

In clinical trials, tirzepatide produced greater average weight loss than semaglutide, with some patients losing up to 20 to 25 percent of their body weight compared to 15 to 17 percent with semaglutide

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Frontiers in physiology

The clinical presentation of DM is often non-specific with lesions showing local growth, a palpable nodule or plaque, and an absence of pigmentation in about 60% of cases [14], especially in the pure type (with prominent fibrosis)