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Among 236 registered patients with T2DM, whose glycemic hemoglobin higher than 6.5% within 3 months, screened at our outpatient clinic, 102 subjects met the following criteria were enrolled: (1) age between 20 and 65 years, (2) diagnosis of type 2 diabetes for more than one year, (3) body mass index (BMI) 18 kg/m2 and 30 kg/m2, (4) fasting triglyceride 150 mg/dl or fasting low-density-lipoprotein cholesterol (LDL) 100 mg/dl and (5) willing to participate in and fill out questionnaires for this trial

Additional symptoms that may occur include headache, fatigue, and general malaise

N., Patten, D

Disadvantages included high cost, slow time course, and ethical concerns

doi: 10.1038/nature26138