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Some publications have summarized preclinical work on mitragynine, suggesting that it is stimulating at low doses and sedating at high doses (Anand & Hosanagar, 2022)

It is widely recognized for promoting tissue repair and accelerating the healing process in various types of injuries, including those affecting muscles, tendons, ligaments, and the gastrointestinal tract

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To replicate specific mitochondrial GSH mechanisms and data from in vivo mice models, a mitochondrial compartment needs to be added