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This timeline reflects the biology of connective tissue healing: the critical proliferative and remodeling phases of tendon and ligament repair typically span four to eight weeks, and supporting angiogenesis and fibroblast migration during that window addresses the mechanistic bottlenecks in healing

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First identified as a potential cognitive enhancer in 1996 by Terranova and colleagues at the French pharmaceutical development firm, Sanofi, Rimonabant was found to be of interest due to its ability to reverse the inhibition of hippocampal synaptic plasticity caused by the CBR1 agonist, WIN 55,212-2

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