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In addition to treating T2DM, metformin modestly reduces body weight gain, which may be achieved by upregulating growth differentiation factor 15 (GDF15) (Day et al., 2019

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In controlled laboratory research, ipamorelin has been extensively characterized for its receptor pharmacology at GHSR-1a, including binding affinity determination (Ki values), G-protein coupling efficiency, and receptor internalization dynamics in heterologous expression systems