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Specifically, carriers of GIPR variants that are pharmacologically classified as loss-of-function variants with reduced cell surface expression, cAMP production, beta arrestin 2 recruitment, internalization, and endosomal signaling have consistently been associated with lower adiposity-related traits, including BMI (103) and nominally lower prevalence of obesity (39, 9799)

Nutraceuticals may assume an increasingly important role within the framework of personalized nutrition and precision medicine ( Despite encouraging findings, current evidence remains fragmented, as existing reviews generally assess nutraceuticals in isolation, with narrow compound focus, limited outcomes, and restricted populations, seldom including pediatric groups

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Normal Ketosis This is the process described above