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In human studies, L-theanine attenuated effects of caffeine on oxygenated hemoglobin, cognition, and mood, suggesting both independent and interactive effects between the two compounds (22)

Valproic acid, a branched chain carboxylic acid, binds to coenzyme A in the cytosol to form valproylCoA, which appears to be a therapeutic metabolite but may lead to mitochondrial DNA depletion in susceptible individuals and is postulated to cause hepatotoxicity

On the other end of the spectrum, some pro-marijuana advocates want to see the government go further and treat cannabis more like alcohol