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- More recently, dual agonistssuch as tirzepatidehave expanded the field by co-activating GLP-1 and GIP receptors, achieving even greater metabolic effects

In animal models of psychosis, liraglutide administration consistently led to a reduction of psychotic-like behavior 119,120,121 , which was also associated with increased brain-derived neurotrophic factor, CREB/p-CREB, and Trk-B expression in the hippocampus and prefrontal cortex 120 , and reduced serum and hippocampal tumor necrosis factor and oxidative stress 121

Weight regain after discontinuing GLP-1 medications is real and documented the STEP 4 trial showed meaningful regain after stopping semaglutide

Understanding how long does it take to notice weight loss can also help set realistic goals during ongoing treatment

Cortisol, the stress hormone, may also be elevated during the adaptation phase