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PT-141 (Bremelanotide) is a man-made, laboratory analogue of alpha-Melanocyte-stimulating hormone (-MSH) that acts as a melanocortin receptor agonist with activity at MC1R, MC3R, and MC4R, and has been shown to influence pathways associated with sexual desire and arousal in the central nervous system

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Trends Pharmacol Sci 37:6272 Lee JH, Chung YC, Bok E et al (2017) Injury-stimulated sonic hedgehog expression in microglia contributes to neuroinflammatory response in the MPTP model of Parkinsons disease

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Multiple groups have studied, characterised, and observed both compounds across in vitro, animal-model, and clinical-research contexts the combined-compound translation is not yet documented in clinical-trial-stage publications