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Glucagon-like peptide 1 receptor agonists: cardiovascular benefits (review)

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PA treatment elevated the expression of genes associated with cholesterol synthesis, such as acyl-CoA C-acyltransferase 1 gene ( ACAT1 ), SREBP-2 , HMGCR , and squalene monooxygenase gene ( SQLE ), as well as genes related to bile acid synthesis, including liver X receptor gene ( LXR ) and cholesterol 7-alpha-hydroxylase gene ( CYP7A1 )

The chart below shows the kind of results seen in major clinical trials, which helps put the efficacy of these medications into perspective

References PubMed Thymosin beta 4 accelerates wound healing (Philp et al., 1999) PubMed Thymosin 4 promotes dermal healing in preclinical models and clinical trials PMC Emerging use of BPC-157 in orthopaedic sports medicine: systematic review PMC Pharmacokinetics, distribution, metabolism, and excretion of BPC-157 in rats and dogs PMC PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation