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Ensure baseline evaluation is thorough and follow-up is accessible if side effects occur

It was found that semaglutide, a long-acting GLP-1RA, could improve symptoms caused by sepsis, reduce body temperature, and decrease the bacterial load in multiple organs, along with the levels of inflammatory factors in plasma and lungs

Dietary modifications: Gradually increase dietary fiber intake to 25-35 grams daily through whole grains, fruits, vegetables, and legumes Maintain adequate hydration (aim for pale yellow urine as an indicator of proper hydration) Avoid excessive caffeine and alcohol, which can contribute to dehydration Consider a fiber supplement (psyllium, methylcellulose) if dietary intake is insufficient, starting with a low dose and increasing gradually Bowel habit optimization: Respond promptly to the urge to defecate rather than delaying Avoid prolonged sitting on the toilet (limit to 5 minutes or less) Do not strain during bowel movements

If you have hypertension and are considering GLP-1 therapy, understanding your current blood pressure control, medication interactions, and underlying cardiovascular risk becomes critical

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