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175, 11461156 10.1111/bph.13825 [DOI] [PMC free article] [PubMed] [Google Scholar] 158.Mustafa A.K., Sikka G., Gazi S.K., Steppan J., Jung S.M., Bhunia A.K.et al

The concentration of reactive oxygen species (ROS) in the ileum is modulated by bacterial load and can inhibit bacterial reflux from the distal intestine through inducible NOS and NADPH oxidase 1, resulting in the production of nitric oxide and superoxide radicals 94

Endocrine reviews , 40 (5), 1318-1352

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Clinical studies have shown that this higher dose leads to greater weight loss compared to the doses used for diabetes management