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(2020) have shown, that human hepatocellular carcinoma (HepG2) cells secrete SELENOP mainly within exosomes, which are stable against cleavage by plasma kallikrein protease (Saito et al., 2004)

Several theories have been proposed to explain the mechanism underlying ovarian aging, including free radical theory, apoptosis, telomere shortening, mitochondrial dysfunction, and inflammation theory (Shi et al., 2016

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The increase in the consumption of processed foods containing high levels of refined carbohydrates and saturated fats has also contributed to the increasing incidence of metabolic diseases, including both MASLD and T2DM (39)

American association of clinical endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity