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Paradoxically, rapidly improving blood sugar can worsen diabetic retinopathy in susceptible individuals, especially those with longstanding, poorly controlled diabetes and high baseline A1c

The much larger opportunity is preventing the downstream cascade: Type 2 diabetes, cardiovascular disease, fatty liver disease, kidney disease & perhaps even cognitive decline

For men who drink regularly and are starting Mounjaro for weight loss, this may be an unexpected benefit

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In agreement, a 1.4-fold faster CL and a 1.6-fold shorter MRT were calculated for GLP-1 LX compared to GLP-1 WT with gPKPDSim (Supplementary Table 4)