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However, in large quantities, it may cause digestive discomfort

(5.1) Recent Major Changes Boxed Warning 6/2026 Warnings and Precautions, Lactic Acidosis (5.1) 6/2026 Indications and Usage for Saxagliptin and Metformin Saxagliptin and metformin hydrochloride extended-release tablets are a combination of saxagliptin, a dipeptidyl peptidase-4 (DPP4) inhibitor, and metformin hydrochloride (HCl), a biguanide, indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus

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In particular, GLP-1 acts on the stomach slowing gastric emptying and, indirectly, enhances glucose uptake from the muscle and adipose tissue