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As an investigational drug, dosing protocols are strictly controlled within clinical settings and should not be replicated outside of supervised trials

Retatrutide has not received marketing authorisation from the MHRA or EMA and is not available through NHS or regulated private prescribing pathways in the UK

Change in GCL was neither associated with the treatment group nor with GCL volume at baseline (Supplementary Table 4)

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Nutrition and lifestyle counseling and healthy behaviors should be the patients and clinicians foundation to maximize overall benefits and cost-effectiveness of GLP-1s for obesity