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Regulation is carried out by binding Nrf2 to a specific DNA sequence known as the antioxidant response element (ARE) found in the promoter regions of genes that encode detoxification enzymes such as NADPH quinone oxidoreductase 1 (NQO1), haem oxygenase 1 (HO-1) and glutathione peroxidase 1 (GPx1), among others [55]

While the treatment is not a cure, it provides significant support for liver-related concerns and symptoms, offering a non-invasive method to improve liver health

This slight increase then leads to an increase in inflammatory cytokines (TNF-alpha, IL-1 beta) in macrophages[ref] Endoplasmic Reticulum (ER) stress, protein misfolding: The endoplasmic reticulum (ER) is an organelle in cells where newly synthesized proteins are folded, lipids are synthesized, and calcium is stored

Approximately one in six patients (up to ~16 %) experience localized reactions at the injection site