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Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)

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One commenter encouraged CMS to identify patient safety measures that are relevant to a broader set of hospitals, including outpatient and observation settings

This is one reason Korean brightening systems often outperform Western products for sensitive skin types

Occasionally, however, insomnia (sometimes with restless legs and muscle jerks) persists as an isolated symptom after other symptoms have disappeared, and may last for many months