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One of the peripheral effects of insulin, that decreases hepatic glucose production, is the suppression of fatty acid release from adipose tissue
Additionally, it engages the mitochondrial pathway by cleaving Bid, a pro-apoptotic Bcl-2 family member, leading to mitochondrial outer membrane permeabilization (MOMP), cytochrome c (Cyt c) release, and subsequent activation of caspase-9
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