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Collect baseline and follow-up (e.g., 1, 3, 6, 12 months) vaginal symptom PROMs, vaginal pH, microbiome sequencing, HbA1c, hydration markers, sex hormones (oestradiol/estrone/SHBG), and weight trajectory

There is growing evidence of a direct link between gastrointestinal function and the brain (Caracciolo et al., 2014)

No negative interaction [24]

27 Glycopyrrolate/eFlow CS was evaluated in 3 pivotal studies in patients with moderate to very severe COPD, known as the Glycopyrrolate for Obstructive Lung Disease Via Electronic Nebulizer (GOLDEN) trials

Activity multipliers: Sedentary (desk job, little exercise): BMR x 1.2 Lightly active (light exercise 1-3 days per week): BMR x 1.375 Moderately active (moderate exercise 3-5 days per week): BMR x 1.55 Very active (hard exercise 6-7 days per week): BMR x 1.725 Using our example, the 40-year-old woman with a BMR of 1,520 who exercises moderately would have a TDEE of 1,520 x 1.55 = 2,356 calories per day