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Neutrophil Extracellular Traps Stimulate Proinflammatory Responses in Human Airway Epithelial Cells

Structural analysis shows they share a fold similar to other GCTs

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What were doing is targeting the root of that process. The teams therapeutic candidate is a first-in-class peptide inhibitor, called FN-2012, designed to break the physical connection between paxillin and FAK within the cells focal adhesion complex a structure that regulates cellular behavior and scar formation

Herein, we report an l-buthionine-sulfoximine (BSO)-based hypertoxic self-assembled peptide derivative (NSBSO) with dual functions of GSH depletion and biosynthesis inhibition for selective tumor ferroptosis and pyroptosis