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10 Risk factors advanced age, polypharmacy, autonomic nervous system disorders, neurological injury (SCI-especially cervical or T6 and above and complete, CVA, peripheral neuropathies), CVD (CHF, MI, arrhythmias, AS), volume depletion, electrolyte imbalance, prolonged bed rest, rapid postural changes, heat exposure, ETOH, Renal disease and other comorbidities as listed under primary and secondary causes of OH

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51 Upregulating SIRT3 expression and activation of the extracellular signal-regulated kinase-Yes-associated protein (ERK-Yap) signaling pathway, as well as the CREB/adiponectin axis may also be involved in the protection of mitochondria by GLP-1

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