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Significant differences in weight loss outcomes were observed among patients with reasonable adherence as compared to those with limited adherence, thus emphasizing the importance of adherence and attrition in real-world digital obesity care

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54 LudwigM.ChengW.GordianD.LeeJ.PaulsenS.HansenS.et al (2021a)

Hepatic effects reported in 0.1% to 1% of patients during clinical trials of topiramate as monotherapy or adjunct therapy for epilepsy included elevated hepatic enzymes (ALT, AST)