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Some studies report significant reductions in TNF- and CRP with GLP-1 RA therapy compared to placebo or other antidiabetic medications (6, 15, 17, 18), while others show non-significant or conflicting results (19, 20)

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When modeling the financial impact of GLP-1 coverage, including potential offsets in cardiometabolic claims, plan sponsors should consider both the high per-member-per-month drug cost and the likelihood that weight and risk factors will revert to baseline after medications are discontinued

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