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Several CVOTs have demonstrated that GLP-1 RAs reduced CV risk in T2DM patients with established ASCVD or high CV risk independent of HbA1c levels

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The subsequent phase 3 trial of tirzepatide demonstrated more effective reductions in the glycated hemoglobin levels and body weight, along with greater overall improvements in the lipid profile compared to semaglutide in patients with T2DM, elevating incretin therapeutic agents to a new level (112)

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