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Lastly, while APOE effects dominated brain profiles, sex effects were more prominent in the periphery, which was also in accordance with a previous study in older (16 months old) APOE-TR mice (Shang et al., 2020), suggesting that regardless of age APOE has a major effect on brain bioenergetics
Reference List FDA
Wiese JG et al., Ann Intern Med, 2000
Selank specifically has shown anxiolytic effects through GABA and serotonin modulation without the dependence risk of benzodiazepines or the side effect profile of SSRIs
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