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doi: 10.1097/01.CHI.0000046908.27264.00

When patients experience reduced oral intake due to nausea or lose fluids through vomiting or diarrhea, intravascular volume decreases, potentially causing orthostatic hypotension (a drop in blood pressure upon standing)

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The once-daily oral administration of oral semaglutide could also potentially improve adherence versus a once-daily injectable, but these data are challenging to incorporate into health economic analyses due to the uncertain impact on costs and effects