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Insulin combined with other drugs Basal insulin therapy is usually the treatment of choice after drugs other than insulin have failed.4,3 As regards drugs that may be used in combination with basal insulin, there are two options (Fig

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What to watch for: New leakage when coughing, sneezing, laughing, or exercising (stress incontinence) Increased urgency or frequency that wasn't present before starting the medication Worsening of existing incontinence symptoms, particularly alongside constipation Practical steps: Start or continue pelvic floor exercises (Kegels) while on GLP-1 medications -- strengthening the pelvic floor proactively is the best defense against these changes Manage constipation aggressively -- fiber, hydration, and movement all help