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Heat accelerates every degradation pathway

It increases the risk for multiple metabolic complications including type 2 diabetes (T2D), metabolic-dysfunction associated steatotic liver disease (MASLD, previously known as non-alcoholic fatty liver disease), cardiovascular disease as well as many mechanical complications such as osteoarthritis and obstructive sleep apnoea (OSA) [3]

The rupture of the physical barrier (OMM) that limits their release into the cytosol constitutes a point-of-no-return in cell death (Martinou and Green, 2001