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Patient-centered factors include comorbidities (established ASCVD or indicators of high-risk established kidney disease, or heart failure), the presence of a compelling need to minimize hypoglycemia, the need to promote weight loss or minimize weight gain, and cost [15, 17]
Outcomes The primary outcome of the SOUL trial was time from randomization to first occurrence of MACE (a composite outcome comprising time to cardiovascular death, time to nonfatal myocardial infarction, or time to nonfatal stroke) in participants receiving oral semaglutide or placebo