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It is often the first-line drug therapy for the condition, and helps to lower blood glucose levels by: making the bodys cells more sensitive to insulin slowing the release of glucose stored in the liver slowing the absorption of glucose from food in the gut However, metformin has a number of Common side effects of metformin can include: digestive problems, such as diarrhea, vomiting, and flatulence abdominal discomfort headaches lack of energy Taking the medication with food may help reduce the risk of digestive problems