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LA has been used to improve age-associated cardiovascular, cognitive, and neuromuscular deficits, and has been implicated as a modulator of various inflammatory signaling pathways

Keywords: glutathione, mitochondria, cholesterol, reactive oxygen species, steatohepatitis, Alzheimer disease INTRODUCTION Glutathione (GSH), the major intracellular thiol compound, is a ubiquitous tripeptide produced by most mammalian cells and it is the main mechanism of antioxidant defense against reactive oxygen species (ROS) and electrophiles