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Therefore, loss of the integrity of melanosome membranes with leakage of these intrinsic toxic agents has the potential to cause self-injury to the melanocytes [6]

It works with a healthy diet and regular exercise

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therefore, translational and clinical studies are needed to confirm preclinical observations in human populations (46, 47)

Under conditions where antioxidant and iron-buffering systems are adequately engaged, NRF2 activation enhances GPX4, superoxide dismutase (SOD), and GSH levels, reduces lipid hydroperoxides, malondialdehyde (MDA), and ROS accumulation [118], and thereby suppresses ferroptotic cell death