2.6 Molecular docking Flexible docking was performed on a defined receptor grid using the extra precision mode (XP) in the Glide application (Schrodinger Release, 2021a) of Maestro (Schrodinger Release, 2021b)
In xenografts, luteolin (100 mg/kg IV) reduced tumor burden and prolonged survival without systemic toxicity, supporting its potential as a safe adjunct targeting tumor stemness ( In Ca Ski cervical cancer cells, luteolin (25100 M) inhibited proliferation and induced intrinsic apoptosis characterized by caspase activation and mitochondrial dysfunction (Pei et al., 2024)
Incubation of GSTP1-1 with quercetin at concentrations of 1 and 10 M for 2 h resulted in reductions in enzymatic activity of 25% and 42%, respectively (Van Zanden et al
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It's something doctors and researchers have started noticing, but as yet we don't have much in the way of solid evidence about a connection
