Sometimes it turns into walking pneumonia
A small retrospective analysis from 2024 suggested modest additional weight loss (13% more) when topiramate was added to semaglutide in patients who had plateaued, but the effect was inconsistent and accompanied by higher adverse-event rates in 40% of participants
Unlike PDE5 inhibitors, it acts primarily on the central nervous system by stimulating melanocortin receptors, particularly MC3R and MC4R, which are involved in sexual behavior and arousal pathways
"What we are seeing now is that because many more people have access to effective medical treatment for weight loss, the number of people experiencing this at one time is much larger, so we are just more aware." And the number of users is only growing
Safe alternatives include gradual dietary modification following the NHS Eatwell Guide, regular physical activity (150 minutes weekly of moderate-intensity exercise), and NHS weight management programmes