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Potential Side Effects, Contraindications, and Safety Considerations Tesamorelin contraindications Disruption of the hypothalamic-pituitary axis Active malignancy Known hypersensitivity Pregnancy Common tesamorelin adverse reactions Arthralgia Injection-site erythema or itching Pain in extremity Peripheral edema Myalgia Growth-axis risks Elevated IGF-1 Glucose intolerance or diabetes Fluid retention Carpal-tunnel symptoms Joint pain Potential excessive tissue growth Malignancy concern Growth hormone and IGF-1 support cell proliferation and survival

( f ) Circulating BHB in OXCT1 iKO mice on CD and KD

* After the first year of follow-up on a semestral/annual basis

It appears to influence growth factors and cellular signaling pathways involved in repair