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Weeks 1-4: 1mg weekly (4mg total, small portion of first vial) Weeks 5-8: 2mg weekly (8mg total) Weeks 9-12: 4mg weekly (16mg total, finish first vial and start second) Weeks 13-16: 6mg weekly (24mg total, continue through second vial) Weeks 17-20: 8mg weekly (32mg total) Weeks 21-24: 8mg weekly maintenance (32mg total) Total peptide required: 116mg over 24 weeks Vials needed: 6 x 20mg vials with some remaining This protocol reaches 8mg maintenance by week 17 and holds there through week 24

The physiological responses produced by the brain in response to GLP-1RA stimulation affect the gastrointestinal tract via the brain-gut axis

Back Marks, V (Feb 2018) 'Rebirth of the Incretin Concept: Its conception and early development', Peptides , 100, 3-9

Semaglutide has a half-life of one week compared to liraglutides 13 hours, allowing for once-weekly (instead of daily) injections

Berthier, C