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Dehydration, eating less, and GI side effects are the likely drivers

Researchers will assess functional outcomes such as cognition and frailty, alongside blood-based biomarkers of agingincluding epigenetic aging, inflammation, and neurofilament light chainas well as detailed analyses of brain pathology

Current Zepbound labeling includes specific contraception precautions around treatment initiation and dose escalation

These medications work within minutes to stop the cycle of vomiting and reduce systemic inflammation

Post-marketing safety data and case reports are also being reviewed to see if this side effect is happening more often than expected