Heterogeneity and Subgroup Analyses Low heterogeneity ( I =14%) was observed across studies, attributable to differences in baseline characteristics, comorbidity prevalence, and outcome definitions
Pairwise distances were generated using the Jukes-Cantor corrected distance algorithm of the program MEGA 4.0 (31)
Thus, it's possible that better efficacy could be achieved with either semaglutide, 2.4 mg, or tirzepatide in PWS but it will be critical to also understand the safety and tolerance for individuals with PWS
No separate medication would be needed
It is usually a combination: Natural cartilage wear Reduced muscle support Biomechanics and alignment Hormonal changes Inflammation Activity history and impact load over time Why estrogen is so protective for joints, bones, and muscle What does estrogen do for the musculoskeletal system