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PLoS One 7(5):e36957

For significant pigmentation reduction or de-tanning, a full protocol of 815 sessions is typically recommended, followed by monthly maintenance

doi: 10.1111/j.1600-6143.2005.01005.x [DOI] [PubMed] [Google Scholar] 134.Ishikawa R, Saito K, Misawa T, Demizu Y, Saito Y

concluded that fasted obese mice treated with TPM for 8 days showed increased mRNA levels of anorexigenic agents, such as POMC, TRH, and CRH, in the hypothalamus [14]