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This blockage in autophagic flux ultimately leads to BAX/BAK oligomerization, activation of Caspase-3-mediated apoptosis, as verified in a POF model rat (Zhou et al., 2023)

Chakravorty S, Hughes K, Craig A (2008) Host response to cytoadherence in Plasmodium falciparum

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Tumors have evolved a unique microenvironment, and typically display a more acidic condition, hypoxia, overexpressed reactive oxygen species (ROS), and glutathione (GSH) owing to their rapid proliferation and metabolism (Mura et al., 2013