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The gamma-glutamyl cycle should be considered not as a mechanism for amino acid transport but rather a generator of extracellular signals, gamma-glutamyl amino acids, that are converted intracellularly to 5-oxoproline, which activates uptake and/or metabolism of amino acids (1, 74, 75)

Uno de los principales factores que limita la eficacia teraputica de la terapia con clulas madre es la supervivencia celular frente al estrs oxidativo e inflamatorio

Hypoxia in the TME could also contribute to the generation of iCAFs, resulting in their enrichment in hypoxic tumour regions [232, 233]

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Guideline on bioanalytical method validation