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Treatment typically begins with 3 mg once daily for 30 days, which serves as a dose escalation step to improve gastrointestinal tolerability rather than a therapeutic dose
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A 5% aliquot of each fraction was used for global proteomics
These neuroprotective effects generalized across GLP-1RAs with variable blood-brain barrier (BBB) permeability (attributable to differences in properties such as molecular size, albumin binding 11 , and potentially receptor-mediated transport into the brain) 12 and diverse experimental conditions 7 , including various rodent species and strains, animal models with or without diabetes mellitus, stroke induction methods, treatment doses and regimens (initiating prior to, during, or even 13 days after stroke induction) 8,13 , indicating a robust class effect
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