Defects in complex I are among the most common causes of mitochondrial diseases, contributing to disorders such as Leigh syndrome, mitochondrial encephalomyopathy and Parkinsons disease by disrupting ATP production and elevating oxidative stress 21,71,72,73
22 Similarly, the large phase 3 EVOKE and EVOKE+ trials of oral semaglutide in early Alzheimers disease failed to slow cognitive decline on the primary endpoint, despite positive effects on certain disease-related biomarkers
Severe gastrointestinal conditions like gastroparesis, since semaglutide naturally slows digestion and may worsen symptoms
Why are TMG and resveratrol included
For these women, midlife weight gain can feel not just like a health issue, but a personal failure