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Namun sebaliknya, meningkatnya kadar radikal bebas akan memicu timbulnya stres oksidatif

Their inherent flexibility allows them to withstand mechanical stress and facilitates their penetration into deeper layers of the skin, including the viable epidermis

Accordingly, neurodegenerative changes are present in other areas of the nervous system, such as the peripheral, autonomic, and enteric nervous systems [15, 16], and -synuclein aggregates may be detected outside the nervous system, including in the digestive tract, skeletal muscles, heart, adrenal glands, kidneys, urogenital system, and skin [22]

Although TFBUT was the primary clinical endpoint, the study was powered on TNF- as a biologically relevant surrogate due to limited prior ophthalmic data for GSH-C4

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