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Again, studies in infants and in animals show that an inability to detoxify the metabolites of acetaminophen is due to lower levels of glutathione and sulfation

Simultaneously, the assembly and activation of the NLRP3 (nucleotide-binding domain-like receptor family pyrin domain containing-3) inflammasome complex, regulated by NF-kB, are enhanced in neurons, microglia, and astrocytes within the trigeminal ganglia, trigeminal nucleus caudalis, and cortical areas (9, 10, 39, 47)

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Jablonska E, Gromadzinska J, Peplonska B, Fendler W, Reszka E, Krol MB, Wieczorek E, Bukowska A, Gresner P, Galicki M, et al

J Anim Plant Sci 31, 15911597