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The absence of functional XBP1 pathway produces Parkinsons Disease (107) and 4-PBA is known to attenuate the severity of several brain diseases, such as Parkinsons (108), Alzheimers (109), and cerebral ischemia (105)

This DA signaling mechanism in the BLA not only facilitates the normal sleep cycle but also contributes to the occurrence of cataplectic attacks in narcoleptics, illustrating its significance in both physiological and pathological aspects of sleep regulation ( Our analysis of dopamine and glutamate levels provides insights into the neuroprotective and cognitive effects of the treatments

As a secondary messenger of free radicals and growth regulators, 4-HNE participates in various pathophysiological processes and act as a bioactive marker, especially in oxidative stress related to diseases (111)

A placebo-controlled trial of L-365,260, a CCKB antagonist, in panic disorder

PMID 17083573