One Mg 2+ ion coordinates motif C and binds at the 3 end (i site) of the RNA primer, facilitating the condensation reaction in RNA chain synthesis, while the second Mg 2+ positions the incoming NTP and stabilizes the charge environment
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Pilo F, Baronciani D, Depau C, Targhetta C, Pani M, Manconi R, et al
System x c - Inhibitors Induce Ferroptosis Certain ferroptosis inducers target the cystine/glutamate exchange transporter, system x c - , which regulates intracellular glutathione content to balance cellular redox
helps in better functioning of the liver
